Helander H F
Gastroenterology. 1976 Dec;71(6):1010-8.
Gastric parietal cells from 44 male adult Sprague-Dawley rats were studied in the electron microscope. The animals were divided into seven groups: normal fasted, normal nonfasted, 4 weeks after vagotomy, 10 weeks after vagotomy and pyloroplasty, 10 weeks after pyloroplasty, 4 weeks after antrectomy, and 10 weeks after antrectomy. Stereological data were obtained from 30 to 40 parietal cells in each animal. In the normal nonfasted rats the parietal cells high up in the glands had a larger secretory surface density than those at deeper levels of the mucosa. Neck parietal cells containing a few mucous granules constituted about 10% of the total number of parietal cells in the normal rats; they were most common in the midgland region. The average parietal cell volume in the normal fasted rats was calculated to be 1100 mu3; the cells were significantly smaller 10 weeks after vagotomy and pyloroplasty and still smaller 10 weeks after antrectomy. In this respect the results after vagotomy and pyloroplasty did not differ from those after pyloroplasty alone. The parietal cell density in the normal fasted rats averaged 144 X 10(3) cells per mm3; in the operated rats (except for the 4-week vagotomized rats) the cells became more numerous. The parietal cell volume density was about equal in all groups of animals, except for the 10-week antrectomized rats, where a significant reduction occurred.
对44只成年雄性Sprague-Dawley大鼠的胃壁细胞进行了电子显微镜研究。将这些动物分为七组：正常禁食组、正常非禁食组、迷走神经切断术后4周组、迷走神经切断术加幽门成形术后10周组、幽门成形术后10周组、胃窦切除术后4周组和胃窦切除术后10周组。从每只动物的30至40个壁细胞中获取体视学数据。在正常非禁食大鼠中，腺体上部的壁细胞比黏膜深层的壁细胞具有更大的分泌表面密度。含有少量黏液颗粒的颈部壁细胞约占正常大鼠壁细胞总数的10%；它们在腺体中部区域最为常见。正常禁食大鼠的平均壁细胞体积经计算为1100立方微米；迷走神经切断术加幽门成形术后10周细胞明显变小，胃窦切除术后10周细胞更小。在这方面，迷走神经切断术加幽门成形术后的结果与单独幽门成形术后的结果没有差异。正常禁食大鼠的壁细胞密度平均为每立方毫米144×10³个细胞；在手术大鼠中（除迷走神经切断术后4周的大鼠外），壁细胞数量增多。除胃窦切除术后10周的大鼠壁细胞体积密度显著降低外，所有动物组的壁细胞体积密度大致相等。
