破伤风溶血素诱导膜损伤的机制：黑脂质膜研究
Mechanism of tetanolysin-induced membrane damage: studies with black lipid membranes.
作者信息
Blumenthal R, Habig W H
出版信息
J Bacteriol. 1984 Jan;157(1):321-3. doi: 10.1128/jb.157.1.321-323.1984.
Abstract
Tetanolysin produced similar rates of leakage of K+ and hemoglobin from erythrocytes. When studied by using cholesterol-containing black lipid membranes, this hemolysin induced conductance steps with a broad frequency distribution. These findings are inconsistent with the formation of structural channels and suggest that tetanolysin acts by causing lipid perturbations.
摘要
破伤风溶血素使红细胞钾离子和血红蛋白的泄漏率相似。在用含胆固醇的黑色脂质膜进行研究时，这种溶血素诱导出频率分布较宽的电导阶跃。这些发现与结构性通道的形成不一致，提示破伤风溶血素通过引起脂质扰动发挥作用。
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