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[脂质自由基——电荷转移和能量转换的可能介质(一种假说)]

[Lipid radicals--possible mediators of charge transfer and energy transformation (a hypothesis)].

作者信息

Dmitriev L F

出版信息

Mol Biol (Mosk). 1983 Nov-Dec;17(6):1297-305.

PMID:6318073
Abstract

A number of enzymatic reactions with the participation of lipid radicals is discussed in the article. It is supposed that NADPH- and NADH-dependent formation of the lipid radicals has a functional importance. The uptake of oxygen by free radicals is considered as one of the reactions of radicals utilization. It is proposed that other reactions with participation of lipid radicals can take place in the membranes of microsomes and mitochondria: the reaction of electron transfer from flavoprotein to cytochrome P448 and the reaction of energy transfer which provide the coupling of oxidation and phosphorylation.

摘要

本文讨论了一些有脂质自由基参与的酶促反应。据推测,脂质自由基的NADPH和NADH依赖性形成具有功能重要性。自由基对氧的摄取被认为是自由基利用的反应之一。有人提出,脂质自由基参与的其他反应可能发生在微粒体和线粒体膜中:从黄素蛋白到细胞色素P448的电子转移反应以及提供氧化与磷酸化偶联的能量转移反应。

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