[自由基脂质中间体在氧化与磷酸化偶联中的可能参与]
[Possible participation of a free-radical lipid intermediate in the coupling of oxidation and phosphorylation].
作者信息
Davletshina L N, Dmitriev L F, Ivanov I I
出版信息
Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(9):25-30.
PMID:6498239
Abstract
Data shown propose two regimes of lipid radicals and oxygen utilization realized in mitochondrial membranes. The first one--lipid peroxidation, i.e. interaction of lipid radical and oxygen is an empty step. In switching this regime to the functional one lipid peroxidation is inhibited. Setting L. -dependent coupling apparatus on phosphorylation in mitochondria takes place in the presence of ADP and Pi.
摘要
所示数据表明，线粒体膜中存在两种脂质自由基和氧利用机制。第一种——脂质过氧化，即脂质自由基与氧的相互作用是一个无效步骤。在将这种机制转换为功能性机制时，脂质过氧化受到抑制。在存在二磷酸腺苷（ADP）和无机磷酸（Pi）的情况下，线粒体中基于脂质依赖性偶联装置的磷酸化发生。
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