An T, Grathwohl M, Frable W J
Am J Clin Pathol. 1984 Jan;81(1):127-32. doi: 10.1093/ajcp/81.1.127.
A breast carcinoma containing osseous metaplasia was examined with electron microscopy. The heterologous components were intermingled closely with the usual infiltrating ductal type of a breast carcinoma. Ultrastructurally, carcinoma cells were distinguished clearly from the various mesenchymal cells composed of active fibroblasts, osteoblasts, and osteoclasts. No intermediate cells were present between the two distinct cell populations. Our findings are consistent with the stromal cell origin of the heterologous components and are discussed with relation to their histogenesis in breast carcinoma.
对一例含有骨化生的乳腺癌进行了电子显微镜检查。异源性成分与常见的浸润性导管型乳腺癌紧密混合。超微结构上，癌细胞与由活跃的成纤维细胞、成骨细胞和破骨细胞组成的各种间充质细胞有明显区别。在这两种不同的细胞群体之间不存在中间细胞。我们的发现与异源性成分的基质细胞起源一致，并就其在乳腺癌中的组织发生进行了讨论。
