Thiry E, Vindevogel H, Leroy P, Pastoret P P, Schwers A, Brochier B, Anciaux Y, Hoyois P
Ann Rech Vet. 1983;14(3):239-45.
The effect of various concentrations of acyclovir on the mean plaque size of pseudorabies virus (SHV), infectious bovine rhinotracheitis virus (IBR virus) and pigeon herpesvirus (PHV) has been studied. Acyclovir significantly reduced the mean plaque size of SHV and PHV, whereas IBR virus was less affected and did only show a reduction of the mean plaque size at the highest concentration of acyclovir used (1000 microM). In vivo effect of acyclovir was tested using pigeons and budgerigars experimentally infected with PHV and rabbits experimentally infected with a very low dose of SHV. Intramuscular injections of acyclovir (100 mg/kg/day; three injections/day) did not prevent the appearance of clinical disease in infected pigeons nor did reduce the level of viral excretion. The same treatment applied, as for the pigeons, before infection protected most of the budgerigars as long as they were treated, but most of them died soon after the end of the treatment. Only one rabbit was protected by the treatment. SHV was recovered in the lung of only one of the treated animals, whereas it was isolated in the lungs of each control animal.
研究了不同浓度的阿昔洛韦对伪狂犬病病毒（SHV）、牛传染性鼻气管炎病毒（IBR病毒）和鸽疱疹病毒（PHV）平均蚀斑大小的影响。阿昔洛韦显著降低了SHV和PHV的平均蚀斑大小，而IBR病毒受影响较小，仅在所用阿昔洛韦的最高浓度（1000微摩尔）时平均蚀斑大小才有所减小。使用经PHV实验感染的鸽子和虎皮鹦鹉以及经极低剂量SHV实验感染的兔子来测试阿昔洛韦的体内效果。肌肉注射阿昔洛韦（100毫克/千克/天；每天三次注射）既不能预防感染鸽子出现临床疾病，也不能降低病毒排泄水平。对鸽子在感染前采用同样的治疗方法，只要治疗，就能保护大多数虎皮鹦鹉，但大多数在治疗结束后不久死亡。只有一只兔子通过治疗得到了保护。在仅一只接受治疗的动物的肺中分离出了SHV，而在每只对照动物的肺中都分离出了该病毒。
