Than G N, Csaba I F, Szabó D G, Bognár Z J, Arany A, Bohn H
Arch Gynecol. 1983;234(1):39-46. doi: 10.1007/BF02114723.
A sensitive radioimmunoassay method has been developed to measure soluble placental protein 12. Using this method trace amounts of PP12 have also been detected in the sera of healthy non-pregnant subjects (24.0 +/- 6.15 micrograms/l). During normal pregnancy serum PP12 levels rose rapidly reaching a peak value of 139.90 +/- 40.26 micrograms/l at 18 weeks. Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). It has been found that in patients with hydatidiform and invasive moles its initial values are extremely high (342.9 +/- 257.9 micrograms/l and 279.3 +/- 103.1 micrograms/l, respectively), much exceeding the non-pregnant and normal pregnant values. After evacuation of hydatidiform moles serum-PP12 rapidly fell to the upper limit of normal at 21-28 days, and to normal values at 8-12 weeks after operation. In patients with invasive mole requiring chemotherapy the rate of fall of PP12 level was slower. In patients with choriocarcinoma serum-PP12 levels were moderately raised (59-132 micrograms/l) and followed the clinical course of the disease. Serum-PP12 levels would seem to be of less value in monitoring patients with trophoblastic tumours than other tumour-markers (hCG, and SP1).
已开发出一种灵敏的放射免疫测定法来测量可溶性胎盘蛋白12。使用该方法还在健康非妊娠受试者的血清中检测到微量的PP12（24.0±6.15微克/升）。在正常妊娠期间，血清PP12水平迅速上升，在18周时达到峰值139.90±40.26微克/升。对31例滋养细胞肿瘤患者（16例葡萄胎、10例侵蚀性葡萄胎和5例绒毛膜癌）进行了PP12的系列测定。已发现，葡萄胎和侵蚀性葡萄胎患者其初始值极高（分别为342.9±257.9微克/升和279.3±103.1微克/升），远超过非妊娠和正常妊娠值。葡萄胎排空后，血清PP12在21 - 28天迅速降至正常上限，术后8 - 12周降至正常水平。对于需要化疗的侵蚀性葡萄胎患者，PP12水平下降速度较慢。绒毛膜癌患者血清PP12水平中度升高（59 - 132微克/升），并随疾病临床进程变化。血清PP12水平在监测滋养细胞肿瘤患者方面似乎比其他肿瘤标志物（hCG和SP1）价值更小。
