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患有先兆子痫、糖尿病或怀有双胞胎的孕妇血清中胎盘特异性组织蛋白12（PP12）的水平。

Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins.

作者信息

Than G N, Csaba I F, Szabó D G, Arany A A, Bognár Z J, Bohn H

出版信息

Arch Gynecol. 1984;236(1):41-5. doi: 10.1007/BF02114867.

DOI:10.1007/BF02114867
PMID:6508361
Abstract

PP12 is one of the recently discovered soluble tissue antigens of the placenta. During normal pregnancy maternal serum PP12 levels rise during the first 18 weeks reaching a mean peak value of 139.9 +/- 40.26 micrograms/l; after that there is a fall to a mean value of 111.9 +/- 42.39 micrograms/l between 28 and 40 weeks. Significantly higher mean serum PP12 levels were found in the third trimester in two high risk pregnancy groups (281.09 +/- 117.08 micrograms/l in pre-eclamptic toxaemia and 203.71 +/- 73.77 micrograms/l in diabetes) while serum PP12 levels remained normal (114.94 +/- 58.06 micrograms/l) in twin pregnancy. The increase of serum PP12 concentration in toxaemia and in diabetes may be of considerable diagnostic significance.

摘要

PP12是胎盘最近发现的可溶性组织抗原之一。在正常妊娠期间，孕妇血清PP12水平在孕18周前升高，平均峰值达到139.9±40.26微克/升；之后下降，在28至40周之间平均值为111.9±42.39微克/升。在两个高危妊娠组的孕晚期发现血清PP12平均水平显著更高（先兆子痫中毒组为281.09±117.08微克/升，糖尿病组为203.71±73.77微克/升），而双胎妊娠时血清PP12水平保持正常（114.94±58.06微克/升）。子痫中毒和糖尿病患者血清PP12浓度升高可能具有重要的诊断意义。

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1
Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins.患有先兆子痫、糖尿病或怀有双胞胎的孕妇血清中胎盘特异性组织蛋白12（PP12）的水平。
Arch Gynecol. 1984;236(1):41-5. doi: 10.1007/BF02114867.
2
Levels of placenta-specific tissue protein 12 (PP12) in serum during normal pregnancy and in patients with trophoblastic tumour.正常妊娠期间及滋养细胞肿瘤患者血清中胎盘特异性组织蛋白12（PP12）的水平。
Arch Gynecol. 1983;234(1):39-46. doi: 10.1007/BF02114723.
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[Placental protein 12 (PP 12) in pregnancy-induced hypertensive diseases].
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Br J Obstet Gynaecol. 1984 Apr;91(4):377-81. doi: 10.1111/j.1471-0528.1984.tb05927.x.

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Am J Reprod Immunol. 2024 Oct;92(4):e13928. doi: 10.1111/aji.13928.
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Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System.进一步证据表明早产发作是一种病态：胰岛素样生长因子系统的参与。
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Placental protein 12 (PP 12), a decidual protein, in pregnancy complicated by diabetes with retinopathy.

本文引用的文献

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[Isolation and characterization of a new placenta specific protein (PP12) (author's transl)].一种新的胎盘特异性蛋白（PP12）的分离与鉴定（作者译）
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Levels of placenta-specific tissue protein 12 (PP12) in serum during normal pregnancy and in patients with trophoblastic tumour.正常妊娠期间及滋养细胞肿瘤患者血清中胎盘特异性组织蛋白12（PP12）的水平。
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Radioimmunoassay of placental protein 12: levels in amniotic fluid, cord blood, and serum of healthy adults, pregnant women, and patients with trophoblastic disease.胎盘蛋白12的放射免疫测定：健康成年人、孕妇及滋养细胞疾病患者羊水、脐血和血清中的水平
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