Dawson R M, Hemington N L, Irvine R F
Biochem Biophys Res Commun. 1983 Nov 30;117(1):196-201. doi: 10.1016/0006-291x(83)91560-7.
Many phospholipases of the A or C types show a very limited ability to hydrolyse phospholipids such as phosphatidylcholine or phosphatidylinositol which adopt a bilayer form when hydrated. The addition of unsaturated 1,2 or 1,3 diacylglycerols to such substances produces a marked stimulation of the attack. In contrast, the hydrolysis of phosphatidylethanolamine, which normally exists in the hexagonal II structure, is not stimulated by diacylglycerol. It is suggested that the liberation of diacylglycerol which often occurs during cell stimulation, may play a part in activating the associated cascade of phospholipid reactions.
许多A类或C类磷脂酶水解磷脂（如磷脂酰胆碱或磷脂酰肌醇）的能力非常有限，这些磷脂在水合时呈双层形式。向这些物质中添加不饱和1,2或1,3二酰基甘油会显著刺激其水解作用。相比之下，通常以六方II型结构存在的磷脂酰乙醇胺的水解不受二酰基甘油的刺激。有人提出，细胞刺激过程中经常发生的二酰基甘油的释放可能在激活相关的磷脂反应级联中起作用。
