变形链球菌的毒力：偶联糖和蔗糖对某些代谢活性及致龋性影响的比较
Virulence of Streptococcus mutans: comparison of the effects of a coupling sugar and sucrose on certain metabolic activities and cariogenicity.
作者信息
Ikeda T, Shiota T, McGhee J R, Otake S, Michalek S M, Ochiai K, Hirasawa M, Sugimoto K
出版信息
Infect Immun. 1978 Feb;19(2):477-80. doi: 10.1128/iai.19.2.477-480.1978.
Abstract
A coupling sugar preparation (sucrose-free [CSSF]), which contains a mixture of sugars, oligosaccharides, and oligosaccharides terminated at the reducing end by sucrose, served as a substrate for growth and acid production by Streptococcus mutans 6715. However, CSSF was a poor substrate for cellular aggregation, glucosyltransferase activity, plaque formation, and adherence of cells to glass surfaces. In the presence of sucrose, CSSF inhibited glucosyltransfer activity and adherence of cells. The substitution of CSSF for sucrose in a rat diet significantly reduced caries score. Furthermore, rats fed diets containing sucrose and CSSF had significantly fewer carious lesions than did rats fed a sucrose diet.
摘要
一种偶联糖制剂（无蔗糖[CSSF]），其包含糖、寡糖以及在还原端以蔗糖终止的寡糖的混合物，用作变形链球菌6715生长和产酸的底物。然而，CSSF是细胞聚集、葡糖基转移酶活性、菌斑形成以及细胞黏附于玻璃表面的不良底物。在蔗糖存在的情况下，CSSF抑制葡糖基转移活性和细胞黏附。在大鼠饮食中用CSSF替代蔗糖可显著降低龋齿评分。此外，喂食含蔗糖和CSSF饮食的大鼠比喂食蔗糖饮食的大鼠龋齿损伤明显更少。
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Virulence of Streptococcus mutans: comparison of the effects of a coupling sugar and sucrose on certain metabolic activities and cariogenicity.变形链球菌的毒力：偶联糖和蔗糖对某些代谢活性及致龋性影响的比较
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