Lewin M J, Reyl-Desmars F, Ling N
C R Seances Acad Sci III. 1983;297(3):123-5.
This study shows that the growth hormone hypothalamic releasing factor (somatocrinin) stimulates the activity of cyclic AMP-dependent protein kinase associated with a purified fraction of hog anterior pituitary secretory granules. Threshold, half-maximal and maximal concentrations (0.3, 35 pM and 10 nM, respectively, in the presence of 50 nM cyclic AMP) are similar to those observed for in vitro stimulation of growth hormone release by somatocrinin.
本研究表明，生长激素下丘脑释放因子（生长激素释放素）可刺激与猪垂体前叶分泌颗粒纯化组分相关的环磷酸腺苷依赖性蛋白激酶的活性。阈值、半数最大浓度和最大浓度（在存在50 nM环磷酸腺苷的情况下，分别为0.3、35 pM和10 nM）与生长激素释放素体外刺激生长激素释放时观察到的浓度相似。
