[抗人巨细胞病毒单克隆抗体的制备]
[Production of monoclonal antibodies against human cytomegalovirus].
作者信息
Mazeron M C, Berbar T, Guillemin M C, Colimon R, Roseto A, Perol Y
出版信息
C R Seances Acad Sci III. 1983;297(6):305-8.
PMID:6318932
Abstract
Cell fusion of Sp2/0, a murine myeloma derived non-secreting variant, with splenic lymphocytes from Mice immunized against human cytomegalovirus, has originated two stable hybridomas producing monoclonal antibodies (IgG) which react specifically with antigens that appear early in infectious cycle and remain localized in the cell nucleus.
摘要
源自小鼠骨髓瘤的非分泌变体Sp2/0与经人巨细胞病毒免疫的小鼠脾淋巴细胞进行细胞融合，产生了两种稳定的杂交瘤，它们分泌的单克隆抗体（IgG）能特异性地与感染周期早期出现并定位于细胞核中的抗原发生反应。
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