Yamamoto N, Chosa T, Koyanagi Y, Tochikura T, Schneider J, Hinuma Y
Cancer Lett. 1984 Jan;21(3):261-8. doi: 10.1016/0304-3835(84)90004-1.
A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negative T-cell line, CCRF-CEM cells. When the viruses were pre-incubated with anti-ATLV-positive human sera, ATLV binding to the cells was clearly inhibited but not by pre-incubation with anti-ATLV-negative sera. These data suggest that: (1) ATLV binds not only to T-cells but also to multiple types of cells of hematopoietic origin; (2) anti-ATLV antibody-positive human sera have the blocking antibody for the binding of ATLV to lymphoid cells.
一种新发现的人类逆转录病毒，成人T细胞白血病病毒（ATLV），通过膜免疫荧光法显示可与包括T细胞、B细胞以及非T、非B细胞系在内的各种造血细胞结合。从成人T细胞白血病病毒产生细胞系的培养液中部分纯化得到的病毒糖蛋白46（gp46）也能有效地与一株成人T细胞白血病病毒阴性的T细胞系CCRF-CEM细胞结合。当病毒与抗成人T细胞白血病病毒阳性的人血清预孵育时，成人T细胞白血病病毒与细胞的结合明显受到抑制，但与抗成人T细胞白血病病毒阴性血清预孵育则不会。这些数据表明：（1）成人T细胞白血病病毒不仅能与T细胞结合，还能与多种造血来源的细胞结合；（2）抗成人T细胞白血病病毒抗体阳性的人血清具有阻断成人T细胞白血病病毒与淋巴细胞结合的抗体。
