Wang J Y, Ledley F, Goff S, Lee R, Groner Y, Baltimore D
Cell. 1984 Feb;36(2):349-56. doi: 10.1016/0092-8674(84)90228-9.
The mouse c-abl gene, part of the sequence of which was captured in Moloney murine leukemia virus to generate the transforming gene (v-abl) of the Abelson murine leukemia virus, has been isolated and characterized. The c-abl locus spans 40 kb in the mouse genome with the v-abl homologies distributed in no less than ten clusters along 25 kb of the cloned DNA. Partial sequence of the v-abl homologous regions indicates that v-abl derived from c-abl mainly by splicing of multiple exons of the c-abl gene. The c-abl sequences can be subdivided into two regions: a tyrosine kinase coding sequence distributed among eight small clusters on the 5' end of the gene and a C-terminal portion consisting of one small and one large cluster, which are needed neither for the tyrosine kinase activity nor for the transforming ability of v-abl. Apparent exon/intron boundaries in the homologous kinase-coding regions of c-abl and c-src are at different locations.
小鼠c-abl基因已被分离和鉴定，其部分序列被莫洛尼氏鼠白血病病毒捕获，从而产生了阿贝尔逊氏鼠白血病病毒的转化基因（v-abl）。c-abl基因座在小鼠基因组中跨度为40kb，v-abl同源序列沿着25kb的克隆DNA分布在不少于十个簇中。v-abl同源区域的部分序列表明，v-abl主要通过c-abl基因多个外显子的剪接从c-abl衍生而来。c-abl序列可分为两个区域：一个酪氨酸激酶编码序列分布在基因5'端的八个小簇中，以及一个C端部分，由一个小簇和一个大簇组成，这两个区域对于酪氨酸激酶活性和v-abl的转化能力都不是必需的。c-abl和c-src同源激酶编码区域中明显的外显子/内含子边界位于不同位置。
