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1
A wild and an attenuated strain of Francisella tularensis differ in susceptibility to hypochlorous acid: a possible explanation of their different handling by polymorphonuclear leukocytes.土拉弗朗西斯菌的野生株和减毒株对次氯酸的敏感性不同：这可能解释了它们被多形核白细胞不同处理的原因。
Infect Immun. 1984 Feb;43(2):730-4. doi: 10.1128/iai.43.2.730-734.1984.
2
Phagocytosis and killing of Francisella tularensis by human polymorphonuclear leukocytes.人多形核白细胞对土拉弗朗西斯菌的吞噬与杀伤作用
Infect Immun. 1983 Feb;39(2):715-20. doi: 10.1128/iai.39.2.715-720.1983.
3
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4
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5
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[Geographical difference in susceptibility to macrolide antibiotics among naturally occurring strains of Francisella tularensis (author's transl)].
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Antibiotic susceptibility in vitro of Francisella tularensis subsp. holarctica isolates from Germany.来自德国的土拉弗朗西斯菌亚种 holarctica 分离株的体外抗生素药敏性。
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1
Multifaceted effects of Francisella tularensis on human neutrophil function and lifespan.土拉弗朗西斯菌对人中性粒细胞功能和寿命的多方面影响。
Immunol Rev. 2016 Sep;273(1):266-81. doi: 10.1111/imr.12445.
2
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis.A型和 B 型土拉弗朗西斯菌 NADPH 氧化酶抑制的多种机制。
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3
Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns.对土拉弗朗西斯菌免疫反应的初始延迟之后是严重脓毒症特有的高细胞因子血症，且与损伤相关分子模式的上调和释放相关。
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4
Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG.土拉弗朗西斯菌菌株对活性氮和氧物种的抗性，特别提及KatG的作用。
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5
Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape.土拉弗朗西斯菌弱毒株通过抑制呼吸爆发和吞噬体逃逸来逃避人类中性粒细胞的杀伤。
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6
Basis for the failure of Francisella tularensis lipopolysaccharide to prime human polymorphonuclear leukocytes.土拉弗朗西斯菌脂多糖无法启动人类多形核白细胞的原因。
Infect Immun. 2006 Jun;74(6):3277-84. doi: 10.1128/IAI.02011-05.
7
Francisella tularensis: taxonomy, genetics, and Immunopathogenesis of a potential agent of biowarfare.土拉弗朗西斯菌：一种潜在生物战剂的分类学、遗传学及免疫发病机制
Annu Rev Microbiol. 2006;60:167-85. doi: 10.1146/annurev.micro.60.080805.142126.
8
Distinct roles of reactive nitrogen and oxygen species to control infection with the facultative intracellular bacterium Francisella tularensis.活性氮和氧物质在控制兼性胞内细菌土拉弗朗西斯菌感染中的不同作用。
Infect Immun. 2004 Dec;72(12):7172-82. doi: 10.1128/IAI.72.12.7172-7182.2004.
9
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells.兼性胞内细菌土拉弗朗西斯菌的减毒株可逃离单核细胞的吞噬体。
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10
Tularemia.兔热病
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本文引用的文献

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Characterization of lactic dehydrogenase of normal human granulocytes.正常人粒细胞乳酸脱氢酶的特性研究
J Lab Clin Med. 1963 May;61:713-23.
2
Immunodiffusion studies with Pasteurella tularensis antigen-rabbit antibody systems.用土拉弗朗西斯菌抗原-兔抗体系统进行免疫扩散研究。
J Immunol. 1962 Nov;89:638-44.
3
The extinction coefficient of cytochrome c.细胞色素c的消光系数。
Biochim Biophys Acta. 1962 Apr 23;58:593-5. doi: 10.1016/0006-3002(62)90073-2.
4
Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig.活疫苗和灭活土拉菌疫苗的预防效果。I. 疫苗的制备及在小白鼠和豚鼠身上的评估。
J Immunol. 1961 Oct;87:415-25.
5
Studies on the fibrinogen, dextran and phytohemagglutinin methods of isolating leukocytes.关于纤维蛋白原、右旋糖酐和植物血凝素分离白细胞方法的研究。
Blood. 1956 May;11(5):436-54.
6
Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens.正常巨噬细胞未能触发氧化代谢爆发：细胞内病原体存活的可能机制。
J Exp Med. 1980 Feb 1;151(2):328-46. doi: 10.1084/jem.151.2.328.
7
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH.吞噬细胞的呼吸爆发与液泡pH值升高有关。
Nature. 1981 Apr 2;290(5805):406-9. doi: 10.1038/290406a0.
8
Demonstration of opsonizing antibodies to Francisella tularensis by leukocyte chemiluminescence.通过白细胞化学发光法检测针对土拉弗朗西斯菌的调理素抗体
Infect Immun. 1980 Aug;29(2):329-34. doi: 10.1128/iai.29.2.329-334.1980.
9
The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes.嗜肺军团菌毒素对人多形核白细胞氧化过程及细菌杀伤作用的影响。
J Infect Dis. 1982 Sep;146(3):328-34. doi: 10.1093/infdis/146.3.328.
10
The killing of pathogens by phagocytes.吞噬细胞对病原体的杀伤作用。
Annu Rev Med. 1981;32:313-26. doi: 10.1146/annurev.me.32.020181.001525.

土拉弗朗西斯菌的野生株和减毒株对次氯酸的敏感性不同：这可能解释了它们被多形核白细胞不同处理的原因。

A wild and an attenuated strain of Francisella tularensis differ in susceptibility to hypochlorous acid: a possible explanation of their different handling by polymorphonuclear leukocytes.

作者信息

Löfgren S, Tärnvik A, Thore M, Carlsson J

出版信息

Infect Immun. 1984 Feb;43(2):730-4. doi: 10.1128/iai.43.2.730-734.1984.

DOI:10.1128/iai.43.2.730-734.1984
PMID:6319290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC264361/
Abstract

We have previously reported that a wild strain of Francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. In the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. The wild and the attenuated strains both induced a respiratory burst in the leukocytes. The difference between the strains in susceptibility to agents produced at the burst could be explained by a difference in susceptibility to hypochlorous acid.

摘要

我们之前曾报道，与减毒株相比，野生型土拉弗朗西斯菌被人类多形核白细胞杀灭的效率要低得多。在本研究中，发现减毒株的杀灭严格依赖氧气。野生株和减毒株均可诱导白细胞产生呼吸爆发。两种菌株对爆发时产生的因子敏感性的差异可以用对次氯酸敏感性的差异来解释。