土拉弗朗西斯菌的野生株和减毒株对次氯酸的敏感性不同：这可能解释了它们被多形核白细胞不同处理的原因。
A wild and an attenuated strain of Francisella tularensis differ in susceptibility to hypochlorous acid: a possible explanation of their different handling by polymorphonuclear leukocytes.
作者信息
Löfgren S, Tärnvik A, Thore M, Carlsson J
出版信息
Infect Immun. 1984 Feb;43(2):730-4. doi: 10.1128/iai.43.2.730-734.1984.
Abstract
We have previously reported that a wild strain of Francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. In the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. The wild and the attenuated strains both induced a respiratory burst in the leukocytes. The difference between the strains in susceptibility to agents produced at the burst could be explained by a difference in susceptibility to hypochlorous acid.
摘要
我们之前曾报道，与减毒株相比，野生型土拉弗朗西斯菌被人类多形核白细胞杀灭的效率要低得多。在本研究中，发现减毒株的杀灭严格依赖氧气。野生株和减毒株均可诱导白细胞产生呼吸爆发。两种菌株对爆发时产生的因子敏感性的差异可以用对次氯酸敏感性的差异来解释。
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