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嗜肺军团菌毒素对人多形核白细胞氧化过程及细菌杀伤作用的影响。

The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes.

作者信息

Friedman R L, Lochner J E, Bigley R H, Iglewski B H

出版信息

J Infect Dis. 1982 Sep;146(3):328-34. doi: 10.1093/infdis/146.3.328.

DOI:10.1093/infdis/146.3.328
PMID:7050255
Abstract

The effect of Legionella pneumophila toxin on selected functions of human polymorphonuclear leukocytes was investigated. Amounts of L. pneumophila toxin that had no effect on leukocyte viability or phagocytosis significantly decreased hexose monophosphate shunt activity and O2 consumption during phagocytosis and bacterial iodination and killing in a dose-dependent fashion. The mechanism of action of this toxin appears to be unique among bacterial products thus far studied.

摘要

研究了嗜肺军团菌毒素对人多形核白细胞某些功能的影响。对白细胞活力或吞噬作用无影响的嗜肺军团菌毒素量，可显著降低吞噬作用、细菌碘化及杀伤过程中的磷酸己糖旁路活性和氧气消耗，且呈剂量依赖性。迄今为止，在已研究的细菌产物中，这种毒素的作用机制似乎是独特的。

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