Dyson J L, Walker P G, Singer A
J Clin Pathol. 1984 Feb;37(2):126-30. doi: 10.1136/jcp.37.2.126.
Twenty eight biopsy specimens of the cervix showed positive immunohistochemical staining when treated with an antiserum raised against an internal capsid antigen of human papillomavirus (HPV). Histological examination of adjoining sections from the same blocks showed a much wider range of abnormalities than those already described in association with HPV infection. The picture was usually diagnostic. It rested chiefly on identifying the koilocyte--the cell with the perinuclear halo that carries the viral antigen in its nucleus--but abnormal keratinisation was also a feature. The accompanying epithelial findings ranged from normal to CIN III (cervical intraepithelial neoplasia). The latter was of an unusual but distinct appearance, in which cytoplasmic maturation was preserved to some degree but in which gross nuclear atypia was seen in all layers of the epithelium.
用针对人乳头瘤病毒（HPV）衣壳内部抗原产生的抗血清处理时，28份宫颈活检标本显示免疫组化染色呈阳性。对来自相同组织块的相邻切片进行组织学检查发现，异常范围比先前描述的与HPV感染相关的异常范围要广泛得多。这种情况通常具有诊断意义。主要依据是识别挖空细胞——即核周有晕、细胞核内携带病毒抗原的细胞——但异常角化也是一个特征。伴随的上皮细胞表现从正常到CIN III（宫颈上皮内瘤变）不等。后者外观不寻常但很独特，其中细胞质成熟在一定程度上得以保留，但上皮各层均可见明显的核异型性。
