乙型肝炎病毒的复制机制：两条DNA链不对称复制的证据

The mechanism of replication of hepatitis B virus: evidence of asymmetric replication of the two DNA strands.

作者信息

Fowler M J, Monjardino J, Tsiquaye K N, Zuckerman A J, Thomas H C

出版信息

J Med Virol. 1984;13(1):83-91. doi: 10.1002/jmv.1890130110.

PMID:6319587

Abstract

In this study we have characterised the DNA replicative intermediates of hepatitis B virus and have shown that HBV-DNA replication is asymmetric. This pattern of HBV replication is similar to that reported for the related duck hepatitis virus (DHBV) and suggests the involvement of a similar reverse transcription process in HBV-DNA replication.

摘要

在本研究中，我们对乙型肝炎病毒的DNA复制中间体进行了表征，并表明乙肝病毒DNA复制是不对称的。这种乙肝病毒复制模式与相关鸭肝炎病毒（DHBV）报道的模式相似，提示类似的逆转录过程参与了乙肝病毒DNA复制。