乙醇对大鼠脑多磷酸肌醇的影响。

Effect of ethanol on rat brain polyphosphoinositides.

作者信息

Shah I R, Uma S, Ramakrishnan C V, Hauser G

出版信息

J Neurochem. 1984 Mar;42(3):873-4. doi: 10.1111/j.1471-4159.1984.tb02762.x.

DOI:10.1111/j.1471-4159.1984.tb02762.x

PMID:6319611

Abstract

Female rats were allowed to consume ethanol during gestation and lactation, and brain polyphosphoinositides of the 21-day-old pups were quantified. Ethanol intake prevented the disappearance of the metabolically labile pools of phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bis-phosphate, which are rapidly degraded in the control group. In contrast, preweaning undernutrition left the size of these pools virtually unchanged, indicating a differential effect of the two nutritional regimens.

摘要

雌性大鼠在妊娠和哺乳期被允许摄入乙醇，然后对21日龄幼崽的脑多磷酸肌醇进行定量分析。乙醇摄入阻止了磷脂酰肌醇-4-磷酸和磷脂酰肌醇-4,5-二磷酸代谢不稳定池的消失，而在对照组中这些物质会迅速降解。相比之下，断奶前营养不良使这些池的大小基本保持不变，这表明两种营养方案具有不同的作用效果。