劳氏相关病毒2非编码区的核苷酸序列：比较确定了在复制和肿瘤发生中重要的保守区域。
Nucleotide sequence of noncoding regions in Rous-associated virus-2: comparisons delineate conserved regions important in replication and oncogenesis.
作者信息
Bizub D, Katz R A, Skalka A M
出版信息
J Virol. 1984 Feb;49(2):557-65. doi: 10.1128/JVI.49.2.557-565.1984.
Abstract
The nucleotide sequence of the regions flanking the long terminal repeat of Rous-associated virus-2 has been determined. The region analyzed spans the ends of the viral genome and includes the terminus of the env gene, the 3' noncoding region, the 5' noncoding region, and the beginning of the gag gene. These data have been compared with sequences available from other avian retroviruses. The comparisons reveal sections which are highly conserved and others which are quite variable. Sequence homologies within the conserved regions suggest details concerning the mode of origin of the src-transducing viruses. Included in the variable section is a region (XSR) found only in certain strains of Rous-derived virus. Its absence from other oncogenic viruses indicates that these sequences are not required to elicit disease.
摘要
劳氏相关病毒2长末端重复序列侧翼区域的核苷酸序列已被确定。所分析的区域跨越病毒基因组的两端，包括env基因的末端、3'非编码区、5'非编码区以及gag基因的起始部分。这些数据已与其他禽逆转录病毒的可用序列进行了比较。比较结果显示出高度保守的区域和变化较大的区域。保守区域内的序列同源性揭示了有关src转导病毒起源方式的细节。可变区域中包含一个仅在某些劳氏衍生病毒株中发现的区域（XSR）。其他致癌病毒中没有该区域，这表明引发疾病并不需要这些序列。
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