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1
Involvement of DNA polymerase alpha in host cell reactivation of UV-irradiated herpes simplex virus.DNA聚合酶α参与紫外线照射的单纯疱疹病毒的宿主细胞复活。
J Virol. 1984 Feb;49(2):598-600. doi: 10.1128/JVI.49.2.598-600.1984.
2
Characterization of an aphidicolin-resistant mutant of herpes simplex virus type 2 which induces an altered viral DNA polymerase.单纯疱疹病毒2型抗阿非科林突变体的特性研究，该突变体诱导病毒DNA聚合酶发生改变。
Virology. 1984 May;135(1):87-96. doi: 10.1016/0042-6822(84)90119-3.
3
A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin.单纯疱疹病毒2型DNA聚合酶基因座内的单碱基变化可赋予对阿非科林的抗性。
J Virol. 1987 Feb;61(2):388-94. doi: 10.1128/JVI.61.2.388-394.1987.
4
On the DNA polymerase-a mutant: immunofluorescence assay of UV-induced thymidine dimers in Aphr-4-2 cells.关于DNA聚合酶α突变体：Aphr-4-2细胞中紫外线诱导胸腺嘧啶二聚体的免疫荧光测定
Somat Cell Mol Genet. 1990 Jan;16(1):49-57. doi: 10.1007/BF01650479.
5
Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.单纯疱疹病毒DNA聚合酶基因中赋予对阿非科林超敏反应的突变。
Nucleic Acids Res. 1983 Aug 11;11(15):5287-97. doi: 10.1093/nar/11.15.5287.
6
Evidence for mutagenic repair in V79 cell mutant with aphidicolin-resistant DNA polymerase-alpha.
Somat Cell Mol Genet. 1984 May;10(3):235-45. doi: 10.1007/BF01535246.
7
Single mutations at many sites within the DNA polymerase locus of herpes simplex viruses can confer hypersensitivity to aphidicolin and resistance to phosphonoacetic acid.单纯疱疹病毒DNA聚合酶基因座内许多位点的单突变可导致对阿非科林超敏并对膦甲酸耐药。
J Gen Virol. 1984 Jan;65 ( Pt 1):1-17. doi: 10.1099/0022-1317-65-1-1.
8
Comparative studies of host-cell reactivation, cellular capacity and enhanced reactivation of herpes simplex virus in normal, xeroderma pigmentosum and Cockayne syndrome fibroblasts.正常、着色性干皮病和科凯恩综合征成纤维细胞中单纯疱疹病毒的宿主细胞复活、细胞能力及增强复活的比较研究
Mutat Res. 1986 Jul;166(1):99-111. doi: 10.1016/0167-8817(86)90045-3.
9
Involvement of eucaryotic deoxyribonucleic acid polymerases alpha and gamma in the replication of cellular and viral deoxyribonucleic acid.真核生物脱氧核糖核酸聚合酶α和γ参与细胞和病毒脱氧核糖核酸的复制。
Biochemistry. 1979 Oct 2;18(20):4431-43. doi: 10.1021/bi00587a025.
10
Aphidicolin resistance in herpes simplex virus type 1 appears to alter substrate specificity in the DNA polymerase.1型单纯疱疹病毒对阿非科林的耐药性似乎改变了DNA聚合酶的底物特异性。
J Virol. 1989 Jun;63(6):2874-6. doi: 10.1128/JVI.63.6.2874-2876.1989.

本文引用的文献

1
Characterization of deoxyribonucleic acid repair synthesis in permeable human fibroblasts.可渗透人成纤维细胞中脱氧核糖核酸修复合成的特性分析
Biochemistry. 1982 May 11;21(10):2557-64. doi: 10.1021/bi00539a040.
2
Effects of DNA polymerase inhibitors on replicative and repair DNA synthesis in ultraviolet-irradiated HeLa cells.DNA聚合酶抑制剂对紫外线照射的HeLa细胞中复制性和修复性DNA合成的影响。
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Nov;42(5):471-80. doi: 10.1080/09553008214551411.
3
Differential responses of log and stationary phase human fibroblasts to inhibition of DNA repair by aphidicolin.对数期和静止期人成纤维细胞对阿非科林抑制DNA修复的不同反应。
Biochim Biophys Acta. 1982 May 31;697(2):229-34. doi: 10.1016/0167-4781(82)90081-1.
4
Inhibitors of repair DNA synthesis.DNA修复合成抑制剂。
Nucleic Acids Res. 1982 Feb 25;10(4):1203-13. doi: 10.1093/nar/10.4.1203.
5
Aphidicolin inhibits repair of DNA in UV-irradiated human fibroblasts.阿非科林抑制紫外线照射后的人成纤维细胞中的DNA修复。
Biochem Biophys Res Commun. 1981 Apr 30;99(4):1088-94. doi: 10.1016/0006-291x(81)90730-0.
6
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.通过一种不同寻常的DNA聚合酶α抑制剂——阿非科林揭示的真核生物DNA复制生物化学新观点。
Cell. 1981 Mar;23(3):647-8. doi: 10.1016/0092-8674(81)90426-8.
7
DNA polymerase alpha mutants from a Drosophila melanogaster cell line.来自黑腹果蝇细胞系的DNA聚合酶α突变体。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7049-53. doi: 10.1073/pnas.77.12.7049.
8
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.具有阿非科林抗性DNA聚合酶α的哺乳动物突变体。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):797-801. doi: 10.1073/pnas.80.3.797.
9
Identification of DNA polymerase(s) involved in the repair of viral and cellular DNA in herpes simplex virus type 2-infected cells.鉴定参与2型单纯疱疹病毒感染细胞中病毒和细胞DNA修复的DNA聚合酶。
Virology. 1983 Sep;129(2):524-8. doi: 10.1016/0042-6822(83)90195-2.
10
Correlation of increased nuclease activity with enhanced virus reactivation.核酸酶活性增加与病毒再激活增强之间的相关性。
Exp Cell Res. 1982 Apr;138(2):485-9. doi: 10.1016/0014-4827(82)90205-1.

DNA聚合酶α参与紫外线照射的单纯疱疹病毒的宿主细胞复活。

Involvement of DNA polymerase alpha in host cell reactivation of UV-irradiated herpes simplex virus.

作者信息

Nishiyama Y, Yoshida S, Maeno K

出版信息

J Virol. 1984 Feb;49(2):598-600. doi: 10.1128/JVI.49.2.598-600.1984.

DOI:10.1128/JVI.49.2.598-600.1984
PMID:6319762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255505/
Abstract

Aphidicolin is a potent inhibitor of both host cell DNA polymerase alpha and herpes simplex virus (HSV)-induced DNA polymerase but has no effect on DNA polymerases beta and gamma of host cells. By using an aphidicolin-resistant mutant (Aphr) of HSV, a possible involvement of DNA polymerase alpha in host cell reactivation of UV-damaged HSV was studied. Plaque formation by UV-irradiated Aphr was markedly inhibited by 1 microgram of aphidicolin per ml, which did not affect the plating efficiency of nonirradiated Aphr. Aphidicolin added before 12 h postinfection inhibited plaque formation by irradiated Aphr, which became aphidicolin insensitive after 36 h postinfection. The results strongly suggest that host cell DNA polymerase alpha is involved in the repair of UV-irradiated HSV DNA.

摘要

阿非科林是宿主细胞DNA聚合酶α和单纯疱疹病毒（HSV）诱导的DNA聚合酶的有效抑制剂，但对宿主细胞的DNA聚合酶β和γ没有影响。通过使用HSV的阿非科林抗性突变体（Aphr），研究了DNA聚合酶α在紫外线损伤的HSV的宿主细胞重新激活中的可能作用。每毫升1微克的阿非科林显著抑制了紫外线照射的Aphr形成噬菌斑，这并不影响未照射的Aphr的铺板效率。感染后12小时前添加阿非科林可抑制照射后的Aphr形成噬菌斑，而感染后36小时后其对阿非科林变得不敏感。结果强烈表明宿主细胞DNA聚合酶α参与了紫外线照射的HSV DNA的修复。