通过一种不同寻常的DNA聚合酶α抑制剂——阿非科林揭示的真核生物DNA复制生物化学新观点。 - Suppr

New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.

作者信息

Huberman J A

出版信息

Cell. 1981 Mar;23(3):647-8. doi: 10.1016/0092-8674(81)90426-8.

DOI:10.1016/0092-8674(81)90426-8

PMID:6784928

Abstract

摘要

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New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.

Cell. 1981 Mar;23(3):647-8. doi: 10.1016/0092-8674(81)90426-8.

Aphidicolin inhibits DNA synthesis by DNA polymerase alpha and isolated nuclei by a similar mechanism.

Nucleic Acids Res. 1981 Sep 25;9(18):4709-19. doi: 10.1093/nar/9.18.4709.

Enhancement of ultraviolet-induced unscheduled DNA synthesis in HeLa cell lysate by aphidicolin in vivo.

Biochem Biophys Res Commun. 1982 Jul 16;107(1):1-5. doi: 10.1016/0006-291x(82)91660-6.

Mitochondrial DNA replication does not involve DNA polymerase alpha.

J Biol Chem. 1980 Dec 25;255(24):11847-52.

The mode of action of aphidicolin on DNA synthesis in isolated nuclei.

Biochem Biophys Res Commun. 1980 Jan 15;92(1):13-9. doi: 10.1016/0006-291x(80)91512-0.

The effect of aphidicolin on the rate of DNA replication and unscheduled DNA synthesis of Bloom syndrome and normal fibroblasts.

Hum Genet. 1982;60(4):357-9. doi: 10.1007/BF00569218.

Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate.

Nucleic Acids Res. 1983 Feb 25;11(4):1197-209. doi: 10.1093/nar/11.4.1197.

Effects of aphidicolin on the recovery of ribosomal RNA synthesis and on the repair of potentially lethal damage in UV irradiated simian and human cells.

Biochem Biophys Res Commun. 1982 Dec 15;109(3):603-11. doi: 10.1016/0006-291x(82)91983-0.

Aphidicolin inhibits the synthesis and joining of short DNA fragments but not the union of 10-kilobase DNA replication intermediates.

Proc Natl Acad Sci U S A. 1983 Jul;80(13):3996-9. doi: 10.1073/pnas.80.13.3996.

Mechanism of DNA polymerase alpha inhibition by aphidicolin.

Biochemistry. 1991 Sep 3;30(35):8590-7. doi: 10.1021/bi00099a014.

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New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.

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