Ito M, Mikawa H, Taniguchi T
Neurology. 1984 Feb;34(2):235-8. doi: 10.1212/wnl.34.2.235.
The mean CSF GABA level in 22 children with infantile spasms was significantly lower than in 35 controls. There was no significant difference between the CSF GABA levels in untreated children and those treated with anticonvulsants, or between uncontrolled and temporarily controlled patients. After treatment with ACTH, CSF GABA levels were lower than before treatment, and seizures disappeared. Brain GABAergic neuronal function may be disturbed in children with infantile spasms, but the decreased CSF GABA level does not directly correlate with the seizures of infantile spasms.
22例婴儿痉挛症患儿脑脊液中γ-氨基丁酸（GABA）的平均水平显著低于35名对照组儿童。未经治疗的儿童与接受抗惊厥药物治疗的儿童脑脊液GABA水平之间，以及未得到控制的患者与暂时得到控制的患者之间，均无显著差异。使用促肾上腺皮质激素（ACTH）治疗后，脑脊液GABA水平低于治疗前，且癫痫发作消失。婴儿痉挛症患儿的脑GABA能神经元功能可能受到干扰，但脑脊液GABA水平降低与婴儿痉挛症的发作并无直接关联。
