Baram T Z, Mitchell W G, Hanson R A, Snead O C, Horton E J
Department of Neurology, University of Southern California, Los Angeles, USA.
Pediatr Neurol. 1995 Sep;13(2):108-10. doi: 10.1016/0887-8994(95)00121-u.
Infantile spasms respond to ACTH, and levels of the hormone in cerebrospinal fluid of untreated infants with this disorder were found to be lower than in age-matched controls. In this study we analyzed cerebrospinal fluid cortisol and ACTH using improved immunoassays in a larger cohort of infants with infantile spasms. Analysis of 20 patients and 15 age-matched controls revealed significantly lower levels of both ACTH and cortisol in the cerebrospinal fluid. These data, combined with the efficacy of ACTH and glucocorticoids for infantile spasms, support an involvement of the brain-adrenal-axis in this disorder.
婴儿痉挛症对促肾上腺皮质激素（ACTH）有反应，且发现患有这种疾病的未经治疗婴儿的脑脊液中该激素水平低于年龄匹配的对照组。在本研究中，我们使用改进的免疫测定法，对更大队列的婴儿痉挛症婴儿的脑脊液皮质醇和ACTH进行了分析。对20名患者和15名年龄匹配的对照进行分析发现，脑脊液中ACTH和皮质醇水平均显著降低。这些数据，结合ACTH和糖皮质激素对婴儿痉挛症的疗效，支持脑-肾上腺轴参与了这种疾病。
