Warenycia M W, McKenzie G M
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):761-4. doi: 10.1016/0278-5846(83)90061-1.
Bipolar multiple unit recording electrodes were implanted in the striata of male Long-Evans rats 5-7 days prior to experimentation. In subsequent experiments, striatal neuronal activity in response to dexamphetamine (1.0 or 2.5 mg/kg i.p.) was recorded in either freely moving or immobilized, artificially-respired rats. Whereas dexamphetamine produced only excitation of striatal neurons in freely moving animals, a multiplicity of responses, ranging from excitation to inhibition, and including biphasic as well as no change responses were observed in immobilized animals. It is concluded that the absence of dexamphetamine-induced behavior in immobilized animals modifies the striatal neuronal response to dexamphetamine, possibly through alteration of the activity of excitatory striatal afferents.
在实验前5 - 7天，将双极多单元记录电极植入雄性Long-Evans大鼠的纹状体中。在随后的实验中，在自由活动或固定、人工呼吸的大鼠中记录纹状体神经元对右旋苯丙胺（1.0或2.5mg/kg腹腔注射）的反应。虽然右旋苯丙胺在自由活动的动物中仅引起纹状体神经元兴奋，但在固定的动物中观察到多种反应，从兴奋到抑制，包括双相反应以及无变化反应。得出的结论是，固定动物中缺乏右旋苯丙胺诱导的行为改变了纹状体神经元对右旋苯丙胺的反应，可能是通过改变兴奋性纹状体传入神经的活动来实现的。
