Warenycia M W, McKenzie G M
Pharmacol Biochem Behav. 1984 Jul;21(1):53-9. doi: 10.1016/0091-3057(84)90130-8.
The effect of dexamphetamine (DEX) on striatal multi-unit activity was examined in freely moving rats and again 24 or 48 hr later during immobilization. Animals which in the freely moving state responded with striatal activation following DEX, 1 mg/kg IP, did not respond to this dose of DEX after immobilization. Similarly with DEX 2.5 mg/kg IP, the incidence of excitatory responses seen in freely moving animals decreased to 18% after immobilization, and the incidence of inhibition and biphasic responses increased from 0% in freely moving animals to 52% in immobilized preparations. The results suggest that the response of striatal neurons to DEX is dependent upon the behavioural state of the animal. Furthermore, these findings indicate that the central actions of DEX are more complex than previously believed, and raises the speculation that the excitatory effects of DEX on striatal neurons may be mediated through excitatory striatal afferents.
在自由活动的大鼠中检测了右旋苯丙胺（DEX）对纹状体多单位活动的影响，并在24或48小时后的固定状态下再次进行检测。在自由活动状态下，腹腔注射1mg/kg DEX后纹状体激活的动物，在固定后对该剂量的DEX无反应。同样，腹腔注射2.5mg/kg DEX时，自由活动动物中出现兴奋性反应的发生率在固定后降至18%，抑制性和双相反应的发生率从自由活动动物中的0%增加到固定制剂中的52%。结果表明，纹状体神经元对DEX的反应取决于动物的行为状态。此外，这些发现表明DEX的中枢作用比以前认为的更复杂，并引发了DEX对纹状体神经元的兴奋作用可能通过兴奋性纹状体传入神经介导的推测。
