Warenycia M W, McKenzie G M
Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):757-60. doi: 10.1016/0278-5846(84)90053-8.
The striatal neuronal response to dexamphetamine, 2.5 mg/kg, was studied in normal freely moving animals and in freely moving animals with unilateral lesions of the parafascicular-centromedian complex. Whereas dexamphetamine produced predominantly excitation of striatal neurons in control animals, the predominant response in lesioned animals was inhibition. In lesioned animals dexamphetamine-induced behavioral activation was unchanged. It is concluded that the PF-CM complex plays an important role in the striatal neuronal response to dexamphetamine in freely moving animals and may be one of the neural substrates conveying sensory feedback from drug-induced behavior to the striatum.
在正常自由活动的动物以及伴有束旁-中央中复合体单侧损伤的自由活动动物中，研究了纹状体神经元对2.5毫克/千克右旋苯丙胺的反应。在对照动物中，右旋苯丙胺主要引起纹状体神经元兴奋，而在损伤动物中，主要反应是抑制。在损伤动物中，右旋苯丙胺诱导的行为激活没有变化。得出的结论是，束旁-中央中复合体在自由活动动物的纹状体神经元对右旋苯丙胺的反应中起重要作用，并且可能是将药物诱导行为的感觉反馈传递到纹状体的神经基质之一。
