Marklund G, Ernberg I, Britton S, Lundberg C
Scand J Infect Dis. 1984;16(1):17-23. doi: 10.3109/00365548409068404.
Tinidazole and metronidazole have been reported beneficial in the treatment of acute anginose infectious mononucleosis. As this disease is caused by the Epstein-Barr virus (EBV), the effect of tinidazole on EBV infection of human B-lymphocytes was investigated. Tinidazole had no effect on induction of EBV determined nuclear antigen (EBNA) or DNA synthesis, while immunoglobulin synthesis was increased in the presence of the drug. Cytotoxicity directed against EBV positive cell lines and long term T-lymphocyte mediated anti-EBV memory, were not affected by tinidazole. In view of these findings we suggest that tinidazole does not act directly on the primary EBV infection in vitro. Nor do our findings indicate any adverse effects of tinidazole on the virus-host relation.
据报道，替硝唑和甲硝唑对治疗急性咽峡炎型传染性单核细胞增多症有益。由于该疾病是由爱泼斯坦-巴尔病毒（EBV）引起的，因此研究了替硝唑对人B淋巴细胞EBV感染的影响。替硝唑对EBV核抗原（EBNA）的诱导或DNA合成没有影响，而在药物存在的情况下免疫球蛋白合成增加。针对EBV阳性细胞系的细胞毒性和长期T淋巴细胞介导的抗EBV记忆不受替硝唑影响。鉴于这些发现，我们认为替硝唑在体外不会直接作用于原发性EBV感染。我们的研究结果也未表明替硝唑对病毒-宿主关系有任何不利影响。
