Kawai K, Kato T, Mori H, Kitamura J, Nozawa Y
Toxicol Lett. 1984 Feb;20(2):155-60. doi: 10.1016/0378-4274(84)90141-3.
The anthraquinone mycotoxins emodin and skyrin were examined for the inhibitory effects on murine leukemia L1210 culture cells, oxidative phosphorylation of rat liver mitochondria, and Na+, K+-activated ATPase activity of rat brain microsomes to find the differences between their modes of toxic action. Skyrin exhibited a stronger inhibitory effect than emodin on the growth of L1210 culture cells. Emodin showed a stronger uncoupling effect than skyrin on mitochondrial respiration. Skyrin inhibited Na+, K+-activated ATPase activity of rat brain microsomes but emodin did not inhibit.
对蒽醌类霉菌毒素大黄素和天精进行了研究，以考察它们对小鼠白血病L1210培养细胞、大鼠肝脏线粒体氧化磷酸化以及大鼠脑微粒体的Na +、K +激活的ATP酶活性的抑制作用，从而找出它们毒性作用方式的差异。天精对L1210培养细胞生长的抑制作用比大黄素更强。大黄素对线粒体呼吸的解偶联作用比天精更强。天精抑制大鼠脑微粒体的Na +、K +激活的ATP酶活性，而大黄素则无抑制作用。
