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多种人干扰素α亚类与共同受体发生交叉反应：它们的结合亲和力与其特定生物学活性相关。

Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.

作者信息

Aguet M, Gröbke M, Dreiding P

出版信息

Virology. 1984 Jan 15;132(1):211-6. doi: 10.1016/0042-6822(84)90105-3.

DOI:10.1016/0042-6822(84)90105-3
PMID:6320534
Abstract

Seven different human interferon (IFN) alpha subtypes were compared with regard to competitive inhibition of specific high-affinity binding of 125I-labeled IFN alpha-2 to human and bovine cells. All IFNs tested (alpha-1, -2, -4, -5, -6, -7, -8) competed for common binding sites. Marked differences in the binding affinities were observed between IFN alpha-1 and IFN alpha-2. The binding affinities of the various subtypes correlated with the respective specific biological activities determined in an antiviral assay. These observations suggest that at least some biological effects of IFNs are initiated by receptor activation and depend quantitatively on the degree of receptor saturation.

摘要

对七种不同的人干扰素（IFN）α亚型进行了比较，观察其对125I标记的IFNα-2与人和牛细胞特异性高亲和力结合的竞争性抑制作用。所有测试的干扰素（α-1、-2、-4、-5、-6、-7、-8）都竞争共同的结合位点。观察到IFNα-1和IFNα-2之间的结合亲和力存在显著差异。各种亚型的结合亲和力与抗病毒试验中确定的各自特异性生物学活性相关。这些观察结果表明，干扰素的至少一些生物学效应是由受体激活引发的，并且在数量上取决于受体饱和程度。

相似文献

1
Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.多种人干扰素α亚类与共同受体发生交叉反应：它们的结合亲和力与其特定生物学活性相关。
Virology. 1984 Jan 15;132(1):211-6. doi: 10.1016/0042-6822(84)90105-3.
2
Different binding of human interferon alpha 1 and alpha 2 to common receptors on human and bovine cells. Studies with recombination interferons produced in Escherichia coli.人干扰素α1和α2与人和牛细胞上共同受体的不同结合。对大肠杆菌中产生的重组干扰素的研究。
J Biol Chem. 1983 Aug 10;258(15):9046-9.
3
Differential binding of human interferon-alpha subtypes to receptors on lymphoblastoid cells.
Biochem Biophys Res Commun. 1983 Jan 27;110(2):537-44. doi: 10.1016/0006-291x(83)91183-x.
4
Binding of human interferon alpha to cells of different sensitivities: studies with internally radiolabeled interferon retaining full biological activity.人α干扰素与不同敏感性细胞的结合：对保留完全生物活性的内部放射性标记干扰素的研究
J Virol. 1983 Mar;45(3):1168-71. doi: 10.1128/JVI.45.3.1168-1171.1983.
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Type I and Type II interferon receptors.I型和II型干扰素受体。
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[Receptor system of interferons].
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Orientation of a human leukocyte interferon molecule on its cell surface receptor: carboxyl terminus remains accessible to a monoclonal antibody made against a synthetic interferon fragment.人白细胞干扰素分子在其细胞表面受体上的取向：羧基末端对于针对合成干扰素片段制备的单克隆抗体仍可及。
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Binding of 125I-labeled human interferon to cell lines with low sensitivity to interferon.
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