Amuro N, Okada S, Goto Y, Shukuya R
Biochim Biophys Acta. 1984 Feb 24;781(1-2):14-7. doi: 10.1016/0167-4781(84)90118-0.
The effect of griseofulvin treatment on the synthesis of cytochrome c oxidase was studied with the liver of the tadpole, Rana catesbeiana. (1) In the liver of tadpole treated with griseofulvin, a ferrochelatase inhibitor, the synthesis of heme a, but not cytochrome c oxidase protein, is inhibited. (2) The apocytochrome c oxidase which is formed in the liver of tadpole treated with griseofulvin is converted to the active holoenzyme by exogenously added heme a.
用牛蛙蝌蚪的肝脏研究了灰黄霉素处理对细胞色素c氧化酶合成的影响。(1)在用灰黄霉素（一种亚铁螯合酶抑制剂）处理的蝌蚪肝脏中，血红素a的合成受到抑制，但细胞色素c氧化酶蛋白的合成不受影响。(2)在用灰黄霉素处理的蝌蚪肝脏中形成的脱辅基细胞色素c氧化酶，通过外源添加血红素a转化为有活性的全酶。
