Johnson F E, Clawson M C, Bashiti H M, Silverberg A B, Broun G O
Cancer. 1984 Apr 15;53(8):1746-51. doi: 10.1002/1097-0142(19840415)53:8<1746::aid-cncr2820530822>3.0.co;2-v.
This report details clinical and pathologic aspects of a case of small cell undifferentiated carcinoma of the esophagus. Transmission electron microscopic examination demonstrated neurosecretory granules, and indirect immunoperoxidase stain for adrenocorticotropic hormone (ACTH) was positive. However, the authors detected no abnormal hormone levels in urine or blood. The calculated tumor doubling time was approximately 2 days. The fulminant nature of this carcinoma was also evident from the rapid clinical progression in spite of surgical excision, radiotherapy, and chemotherapy.
本报告详细阐述了一例食管小细胞未分化癌的临床和病理特征。透射电子显微镜检查显示有神经分泌颗粒，促肾上腺皮质激素（ACTH）间接免疫过氧化物酶染色呈阳性。然而，作者在尿液或血液中未检测到异常激素水平。计算得出的肿瘤倍增时间约为2天。尽管进行了手术切除、放疗和化疗，但临床进展迅速，该癌症的暴发性特征也很明显。
