食管鳞状细胞癌：组织学标准及其预后意义。

Edwards J M, Hillier V F, Lawson R A, Moussalli H, Hasleton P S

Department of Pathology, Wythenshawe Hospital, Manchester, UK.

Br J Cancer. 1989 Mar;59(3):429-33. doi: 10.1038/bjc.1989.87.

One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intravenous tumour infiltration. Presence of tumour in the middle third of the oesophagus, infiltration through the muscularis propria, severe tumour necrosis, glandular or small cell tumour differentiation, lymphatic invasion and lack of peritumoural fibrosis were all factors which tended to worsen prognosis. None of these factors reached statistical significance. The degree of squamous differentiation had no effect on survival.

回顾了100例食管鳞状细胞癌切除病例，并研究了一系列与生存时间相关的组织学标准。在评估生存情况时，有两个组织学特征很重要。良好的预后因素是对肿瘤有明显的淋巴细胞反应以及无肿瘤静脉浸润。肿瘤位于食管中段、浸润穿过固有肌层、严重肿瘤坏死、腺性或小细胞肿瘤分化、淋巴浸润以及无肿瘤周围纤维化都是倾向于使预后恶化的因素。这些因素均未达到统计学意义。鳞状分化程度对生存无影响。