逆转录病毒癌基因v-erb-B编码的膜糖蛋白在结构上与酪氨酸特异性蛋白激酶相关。
The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.
作者信息
Privalsky M L, Ralston R, Bishop J M
出版信息
Proc Natl Acad Sci U S A. 1984 Feb;81(3):704-7. doi: 10.1073/pnas.81.3.704.
Abstract
Avian erythroblastosis virus can transform both fibroblasts and erythroid cells to neoplastic growth. A locus within the virus genome, v-erb B, encodes a membrane glycoprotein essential for the oncogenic properties of the virus. No biochemical function has until now been attributed to the v-erb B protein. We report here that the v-erb B glycoprotein shares strong structural homologies with the tyrosine-specific protein kinases encoded by certain retroviral oncogenes. The patterns of amino acid conservation between the tyrosine-specific protein kinases and the v-erb B protein, and between the v-erb B protein and the catalytic subunit of bovine protein kinase, suggest a possible functional as well as structural relatedness.
摘要
禽成红细胞增多症病毒可将成纤维细胞和红细胞转化为肿瘤性生长。病毒基因组中的一个位点v-erb B编码一种对病毒致癌特性至关重要的膜糖蛋白。迄今为止，v-erb B蛋白尚无生化功能。我们在此报告，v-erb B糖蛋白与某些逆转录病毒癌基因编码的酪氨酸特异性蛋白激酶具有很强的结构同源性。酪氨酸特异性蛋白激酶与v-erb B蛋白之间，以及v-erb B蛋白与牛蛋白激酶催化亚基之间的氨基酸保守模式，提示了可能的功能以及结构相关性。
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The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.逆转录病毒癌基因v-erb-B编码的膜糖蛋白在结构上与酪氨酸特异性蛋白激酶相关。
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