人类胃泌素基因的结构。
Structure of a human gastrin gene.
作者信息
Wiborg O, Berglund L, Boel E, Norris F, Norris K, Rehfeld J F, Marcker K A, Vuust J
出版信息
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1067-9. doi: 10.1073/pnas.81.4.1067.
Abstract
A gastrin gene was isolated from a genomic library of human DNA. The human gastrin gene is about 4100 base pairs long and contains two intervening sequences. Thus, a 3500-base-pair intervening sequence is located 5 base pairs proximal to the ATG initiator codon, while a 129-base-pair intervening sequence separates the region coding for the principal hormonal form of gastrin, the heptadecapeptide, from the region coding for the major amino-terminal portion of the gastrin precursor. The 5' flanking region of the gene contains the conserved sequences, T-A-T-A-A and G-A-C-T-C-A-T-A-T, in positions similar to those of other eukaryotic genes.
摘要
从人类DNA基因组文库中分离出一种胃泌素基因。人类胃泌素基因长约4100个碱基对，包含两个间隔序列。因此，一个3500个碱基对的间隔序列位于距ATG起始密码子近端5个碱基对处，而一个129个碱基对的间隔序列将编码胃泌素主要激素形式（十七肽）的区域与编码胃泌素前体主要氨基末端部分的区域分隔开。该基因的5'侧翼区域在与其他真核基因相似的位置含有保守序列T-A-T-A-A和G-A-C-T-C-A-T-A-T。
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