对禽肉瘤病毒转化蛋白pp60src具有特异性的单克隆抗体。
Monoclonal antibodies specific for the avian sarcoma virus transforming protein pp60src.
作者信息
Tanaka T, Kurth R
出版信息
Virology. 1984 Feb;133(1):202-10. doi: 10.1016/0042-6822(84)90440-9.
Monoclonal antibodies to avian sarcoma/leukosis virus-coded transforming, structural, and polymerase proteins have been developed. In this first communication, a monoclonal antibody to pp60src will be characterized. The antibody can bind to pp60src in radioimmunoassays, precipitates this antigen in protein kinase tests, and demonstrates in immunofluorescence investigations that pp60src has different intracellular localizations depending on whether RSV-transformed avian or mammalian cells are studied.
已开发出针对禽肉瘤/白血病病毒编码的转化蛋白、结构蛋白和聚合酶蛋白的单克隆抗体。在这篇首次通讯中，将对一种针对pp60src的单克隆抗体进行特性描述。该抗体在放射免疫测定中能与pp60src结合，在蛋白激酶试验中沉淀这种抗原，并在免疫荧光研究中表明，根据所研究的是劳斯肉瘤病毒转化的禽类细胞还是哺乳动物细胞，pp60src具有不同的细胞内定位。
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