Adkins B, Hunter T, Sefton B M
J Virol. 1982 Aug;43(2):448-55. doi: 10.1128/JVI.43.2.448-455.1982.
P105 and P110, the presumptive transforming proteins of PRCII avian sarcoma virus, have been found to be present in transformed chicken cells in two forms: as monomers and as part of a complex which contains both a 50,000-dalton and a 90,000-dalton cellular phosphoprotein. The 90,000-dalton cellular protein was found to be identical to one of the proteins in chicken cells whose synthesis is induced by stress. The 50,000-dalton protein was found to contain phosphotyrosine when isolated from the complex and therefore may be a substrate for the tyrosine protein kinase activity which is associated with P105 and P110. These same two cellular phosphoproteins have previously been shown to be present in a complex with pp60src, the tyrosine protein kinase which is the transforming protein of Rous sarcoma virus. However, not all avian sarcoma virus transforming proteins with associated tyrosine protein kinase activities form a complex efficiently with these cellular proteins. Little if any of P90, the putative transforming protein of Yamaguchi 73 virus, was found in a complex with the 50,000-dalton and 90,000-dalton cellular phosphoproteins.
P105和P110是PRCII禽肉瘤病毒的推定转化蛋白，已发现它们以两种形式存在于转化的鸡细胞中：作为单体以及作为一种复合物的一部分，该复合物包含一种50000道尔顿和一种90000道尔顿的细胞磷蛋白。已发现90000道尔顿的细胞蛋白与鸡细胞中一种受应激诱导合成的蛋白相同。从复合物中分离出的50000道尔顿蛋白被发现含有磷酸酪氨酸，因此可能是与P105和P110相关的酪氨酸蛋白激酶活性的底物。先前已证明这两种相同的细胞磷蛋白与pp60src（劳氏肉瘤病毒的转化蛋白酪氨酸蛋白激酶）存在于一种复合物中。然而，并非所有具有相关酪氨酸蛋白激酶活性的禽肉瘤病毒转化蛋白都能有效地与这些细胞蛋白形成复合物。山口73病毒的推定转化蛋白P90几乎没有（如果有的话）与50000道尔顿和90000道尔顿的细胞磷蛋白形成复合物。
