炎症滑膜组织合成的一种因子诱导软骨细胞中胶原酶的合成。
Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue.
作者信息
Kerwar S S, Ridge S C, Landes M J, Nolan J C, Oronsky A L
出版信息
Agents Actions. 1984 Jan;14(1):54-7. doi: 10.1007/BF01966833.
PMID:6322548
Abstract
Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.
摘要
在培养中生长的兔炎症滑膜组织合成一种因子，该因子可诱导软骨细胞和软骨中胶原酶的合成。滑膜组织对该因子的合成可被放线菌酮抑制，但不被吲哚美辛抑制。该因子的表观分子量为30,000，对热和胰蛋白酶处理稳定，但可被酸灭活。软骨细胞中胶原酶合成的诱导在6小时的延迟期后发生。
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