软骨基质降解的部位。
The site of cartilage matrix degradation.
作者信息
Dingle J T, Dingle T T
出版信息
Biochem J. 1980 Aug 15;190(2):431-8. doi: 10.1042/bj1900431.
Abstract
- A 'cavity' organ culture method was developed, which allowed the insertion within bovine nasal cartilage of 10 microliter of 35S-labelled proteoglycan aggregate. 2. Stimulation of the tissue with retinol or catabolin led to degradation of both the cartilage matrix and the proteoglycan within the cavity. 3. Proteoglycan aggregate trapped in polyacrylamide beads was not broken down in the cavities of living cartilage, except under autolytic conditions. 4. It is suggested that degradation of proteoglycan aggregate by chondrocytes occurs in a pericellular region.
摘要
- 开发了一种“腔室”器官培养方法，该方法允许将10微升35S标记的蛋白聚糖聚集体插入牛鼻软骨内。2. 用视黄醇或分解代谢素刺激组织会导致腔室内软骨基质和蛋白聚糖的降解。3. 被困在聚丙烯酰胺珠中的蛋白聚糖聚集体在活软骨腔室内不会分解，除非在自溶条件下。4. 有人提出软骨细胞对蛋白聚糖聚集体的降解发生在细胞周围区域。
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本文引用的文献
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Hyaluronic acid in cartilage and proteoglycan aggregation.软骨中的透明质酸与蛋白聚糖聚集
Biochem J. 1974 Jun;139(3):565-81. doi: 10.1042/bj1390565.
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Aggregation of cartilage proteoglycans. I. The role of hyaluronic acid.软骨蛋白聚糖的聚集。I. 透明质酸的作用。
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Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis.类风湿关节炎中软骨-血管翳交界处的电子显微镜研究。
Arthritis Rheum. 1975 Sep-Oct;18(5):475-83. doi: 10.1002/art.1780180507.
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Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory.1978年赫伯登演讲。关节损伤控制的近期研究：斯特兰韦斯研究实验室的贡献。
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