Vecchio F M, Fabiano A, Ghirlanda G, Manna R, Massi G
Am J Clin Pathol. 1984 Apr;81(4):521-6. doi: 10.1093/ajcp/81.4.521.
A case of fibrolamellar carcinoma (FLC) in a noncirrhotic liver of a 20-year-old man is described. Gross features and the presence, among the tumor cells, of bile ducts, of thick-walled blood vessels and nerves, and, ultrastructurally, of myofibroblast-like cells are the most significant findings, suggesting that FLC is the malignant counterpart of focal nodular hyperplasia with oncocytic change. Histochemical and immunohistochemical methods demonstrate the presence inside the oncocytic tumor cells of copper, copper-binding protein, and alpha 1 antitrypsin. The pathogenesis and the significance of these findings then are discussed and related to the restricted capacity of oncocytic cells to fulfill normal cellular function.
本文描述了一名20岁男性非肝硬化肝脏中发生的纤维板层癌（FLC）病例。大体特征以及肿瘤细胞中存在胆管、厚壁血管和神经，超微结构上存在肌成纤维细胞样细胞是最显著的发现，提示FLC是具有嗜酸性细胞改变的局灶性结节性增生的恶性对应物。组织化学和免疫组织化学方法证明嗜酸性肿瘤细胞内存在铜、铜结合蛋白和α1抗胰蛋白酶。然后讨论了这些发现的发病机制和意义，并将其与嗜酸性细胞履行正常细胞功能的能力受限相关联。
