Bryan C S, Morgan S L, Jordan A B, Smith C W, Sutton J P, Gangemi J D
Antimicrob Agents Chemother. 1984 Jan;25(1):37-9. doi: 10.1128/AAC.25.1.37.
One gram of ceftriaxone was given intravenously to 15 patients approximately 2 h before cardiopulmonary bypass surgery. Ceftriaxone levels in plasma (mean +/- standard deviation) were 60.4 +/- 18.8 micrograms/ml (range, 17.0 to 96.0 micrograms/ml) at the beginning of bypass, 44.2 +/- 16.6 micrograms/ml (range, 9.4 to 78.6 micrograms/ml) at the end of bypass, and 19.6 +/- 9.6 micrograms/ml (range, 4.2 to 47.1 micrograms/ml) the following morning, 18.1 to 24.7 h after infusion of ceftriaxone. Concentrations in the sternal bone were 4.7 +/- 2.1 micrograms/g (range, 1.0 to 10.1 micrograms/g; tissue-to-plasma ratios, 0.066 +/- 0.036). Concentrations in the atrial appendage were 7.7 +/- 1.8 microgram/g (range, 3.6 to 10.2 micrograms/g; tissue-to-plasma ratios, 0.143 +/- 0.062). These data suggest that a single dose of ceftriaxone might be useful for prevention of infection due to susceptible pathogens.
在体外循环心脏手术前约2小时，给15名患者静脉注射1克头孢曲松。体外循环开始时血浆中头孢曲松水平（均值±标准差）为60.4±18.8微克/毫升（范围为17.0至96.0微克/毫升），体外循环结束时为44.2±16.6微克/毫升（范围为9.4至78.6微克/毫升），次日上午，即输注头孢曲松后18.1至24.7小时，为19.6±9.6微克/毫升（范围为4.2至47.1微克/毫升）。胸骨中的浓度为4.7±2.1微克/克（范围为1.0至10.1微克/克；组织与血浆比率为0.066±0.036）。心耳中的浓度为7.7±1.8微克/克（范围为3.6至10.2微克/克；组织与血浆比率为0.143±0.062）。这些数据表明，单剂量头孢曲松可能有助于预防易感病原体引起的感染。
