Parker F B, Greiner-Hayes C, Tomar R H, Markowitz A H, Bove E L, Marvasti M A
Ann Surg. 1983 Feb;197(2):147-51. doi: 10.1097/00000658-198302000-00005.
The outcome of patients developing early bacteremia was investigated in 890 patients following cardiac valve replacement over a ten-year period. Thirty-two patients developed bacteremia during the hospital recovery period from valve replacement (3.6%). Sixty per cent of the organisms involved were gram-negative. Twenty-one of 23 patients had white blood counts greater than 14,000 at the time of positive blood culture. Nine patients died, seven of septic complications. Only two patients developed endocarditis. No patient with bacteremia diagnosed within ten days of surgery developed endocarditis, however two patients developed gram-negative sepsis in this period. The diagnosis and treatment of bacteremia requires continual vigilance if significant mortality and morbidity are to be averted.
在十年期间，对890例接受心脏瓣膜置换术的患者发生早期菌血症的结果进行了调查。32例患者在瓣膜置换术后的医院康复期发生菌血症（3.6%）。所涉及的微生物中有60%为革兰氏阴性菌。23例患者中有21例在血培养阳性时白细胞计数超过14,000。9例患者死亡，7例死于败血症并发症。只有2例患者发生心内膜炎。在手术后十天内诊断出菌血症的患者中，没有一例发生心内膜炎，然而在此期间有2例患者发生革兰氏阴性败血症。如果要避免严重的死亡率和发病率，菌血症的诊断和治疗需要持续保持警惕。
