Wilson J N, Wilson S P, Eaton R P
Arteriosclerosis. 1984 Mar-Apr;4(2):147-53. doi: 10.1161/01.atv.4.2.147.
The present investigation was designed to examine the influence of dietary fibers with differing soluble fiber compositions upon the metabolism of lipids in a hyperlipemic animal model, the Zucker fatty rat. The response to fiber was examined using a diet supplemented with cellulose, oat bran, or pectin which have a soluble/insoluble fiber ratio of 0:100, 33:66, and 100:0, respectively. These fibers provided 10% of the total diet weight; the control diet contained no fiber. A rapid increase in plasma triglyceride concentration was observed in all animals given fiber-supplemented diets in correlation with the increased carbohydrate content of the defined diets relative to the prestudy diets. This increase in plasma triglyceride was due to increased production of triglycerides with no change in the rates of clearance. The plasma total cholesterol levels were relatively constant on all diets. However, after 7 weeks on the pectin-supplemented diet, rats showed a 39% elevation in HDL and a 44% reduction in LDL concentration. This diet also resulted in reduced weight gain, in spite of a caloric intake equivalent to the control diets. Our data suggest that the ability of dietary fiber to alter plasma lipoproteins might be predictable from the soluble fiber composition or the pectin content of a given dietary fiber in this model of genetic endogenous hyperlipemia.
本研究旨在探讨不同可溶性纤维组成的膳食纤维对高脂血症动物模型——Zucker肥胖大鼠脂质代谢的影响。使用分别添加纤维素、燕麦麸或果胶的日粮来研究对纤维的反应，这些日粮的可溶性/不溶性纤维比例分别为0:100、33:66和100:0。这些纤维占日粮总重量的10%；对照日粮不含纤维。与预研究日粮相比，所有给予添加纤维日粮的动物血浆甘油三酯浓度均迅速升高，这与特定日粮中碳水化合物含量增加有关。血浆甘油三酯的这种升高是由于甘油三酯生成增加，而清除率没有变化。所有日粮的血浆总胆固醇水平相对恒定。然而，在补充果胶的日粮喂养7周后，大鼠的高密度脂蛋白升高了39%，低密度脂蛋白浓度降低了44%。尽管热量摄入与对照日粮相当，但这种日粮也导致体重增加减少。我们的数据表明，在这种遗传性内源性高脂血症模型中，膳食纤维改变血浆脂蛋白的能力可能可以从给定膳食纤维的可溶性纤维组成或果胶含量预测出来。
