Ney D M, Lasekan J B, Shinnick F L
Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison 53706.
J Nutr. 1988 Dec;118(12):1455-62. doi: 10.1093/jn/118.12.1455.
The effect of oat fiber on VLDL, LDL and HDL composition was investigated by feeding male Sprague-Dawley rats diets containing 1.0% cholesterol and 0.2% cholic acid, and 6% dietary fiber from oat bran, high-fiber oat flour or a processed oat product for 20 d. Compared to cholesterol-fed cellulose controls, all oat fibers altered the response to cholesterol feeding as indicated by 25-45% lower total lipoprotein cholesterol, 40-60% lower VLDL + LDL cholesterol, and 25-40% higher HDL cholesterol contents, P less than 0.01. The effect of the oat fibers on VLDL composition was especially pronounced as demonstrated by 30-65% lower VLDL protein, VLDL apo E and plasma apo B concentrations. The processed oat product which contained 40% more soluble fiber than oat bran or oat flour normalized the lipoprotein profile associated with ingestion of the atherogenic diet significantly more than oat bran or oat flour. Concentration of total lipoprotein cholesterol and distribution of apo E among the VLDL and LDL fractions in the processed oat product group were similar to controls not fed cholesterol. These data indicate that ingestion of oat fiber tends to normalize the lipoprotein profile induced by feeding an atherogenic diet in the rat, and that the hypocholesterolemic effect of oat fiber is associated with its soluble fiber content.
通过给雄性斯普拉格-道利大鼠喂食含有1.0%胆固醇、0.2%胆酸以及6%来自燕麦麸、高纤维燕麦粉或一种加工燕麦产品的膳食纤维的日粮20天，研究了燕麦纤维对极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）组成的影响。与喂食胆固醇的纤维素对照组相比，所有燕麦纤维均改变了对胆固醇喂食的反应，表现为总脂蛋白胆固醇降低25 - 45%、VLDL + LDL胆固醇降低40 - 60%、HDL胆固醇含量升高25 - 40%，P < 0.01。燕麦纤维对VLDL组成的影响尤为显著，表现为VLDL蛋白、VLDL载脂蛋白E和血浆载脂蛋白B浓度降低30 - 65%。与燕麦麸或燕麦粉相比，含有比燕麦麸或燕麦粉多40%可溶性纤维的加工燕麦产品能更显著地使与摄入致动脉粥样化日粮相关的脂蛋白谱正常化。加工燕麦产品组中的总脂蛋白胆固醇浓度以及载脂蛋白E在VLDL和LDL组分中的分布与未喂食胆固醇的对照组相似。这些数据表明，摄入燕麦纤维倾向于使大鼠因喂食致动脉粥样化日粮而诱导的脂蛋白谱正常化，并且燕麦纤维的降胆固醇作用与其可溶性纤维含量有关。
