O'Sullivan G, Durham P J, Smith J R, Campbell R S
Aust Vet J. 1984 Jan;61(1):1-4. doi: 10.1111/j.1751-0813.1984.tb07119.x.
Severe enteritis was produced in recently weaned, 8-week old pups 3 to 9 days after being given parvovirus by mouth. The most severe manifestations of disease were observed 7 days after infection, when one pup died. Viraemia was detected on days 4 and 5 and a severe leucopenia was present 6 to 8 days after infection. Antibody was demonstrated in serum 4 days after infection, high titres being present 3 days later. Sequential pathological studies revealed necrosis of Peyer's patches on day 3. Between days 5 and 7 typical lesions of the disease became widespread with necrosis of tonsil and thymus being prominent. By the fifth day after infection viral inclusion bodies were numerous. Virus isolation from tissues was greatest at this stage and had diminished by the seventh day. Although tissue repair was well advanced by the tenth day thymic necrosis remained prominent and villous atrophy was still present on day 13. Based on these findings a possible pathogenesis is discussed.
在最近断奶的8周龄幼犬经口接种细小病毒3至9天后引发了严重肠炎。感染7天后观察到疾病的最严重表现，此时有1只幼犬死亡。在感染后第4天和第5天检测到病毒血症，感染后6至8天出现严重白细胞减少。感染后4天血清中出现抗体，3天后出现高滴度抗体。连续的病理学研究显示，第3天派伊尔结出现坏死。在第5天至第7天期间，该病的典型病变广泛出现，扁桃体和胸腺坏死明显。感染后第5天，病毒包涵体大量出现。此时从组织中分离出的病毒量最多，到第7天时减少。尽管到第10天时组织修复进展良好，但胸腺坏死仍然明显，第13天时绒毛萎缩依然存在。基于这些发现，讨论了一种可能的发病机制。
