Durham P J, Lax A, Johnson R H
Res Vet Sci. 1985 Mar;38(2):209-19.
Calves held in isolation showed a progressive decline in maternally derived antibody titres to bovine parvovirus but low concentrations of inhibitors resistant to heat and kaolin treatment persisted as the animals matured. These inhibitors had both haemagglutination inhibition and plaque neutralising activity and were considered to be of non-specific origin. Following oral challenge with bovine parvovirus, calves developed mild to moderate diarrhoea, with lymphopenia and viraemia. Sequential virological and immunofluorescent studies showed that the virus initially infected tonsils and intestinal tract, subsequently spreading to systemic lymphoid tissues. Histological and scanning electron microscopic examinations revealed moderate small intestinal villus atrophy and fusion due to crypt damage, together with lymphoid necrosis predominantly associated with the intestinal tract and thymus. Although the disease was not very severe, this may have been because the low parasite burden in the animals reduced mitotic activity in susceptible tissues.
隔离饲养的犊牛对牛细小病毒的母源抗体滴度呈逐渐下降趋势，但随着动物成熟，对热和高岭土处理具有抗性的低浓度抑制剂持续存在。这些抑制剂具有血凝抑制和蚀斑中和活性，被认为是非特异性来源。用牛细小病毒进行口服攻毒后，犊牛出现轻度至中度腹泻，伴有淋巴细胞减少和病毒血症。连续的病毒学和免疫荧光研究表明，该病毒最初感染扁桃体和肠道，随后扩散到全身淋巴组织。组织学和扫描电子显微镜检查显示，由于隐窝损伤，小肠绒毛出现中度萎缩和融合，同时主要与肠道和胸腺相关的淋巴样坏死。尽管疾病不太严重，但这可能是因为动物体内寄生虫负担低，降低了易感组织中的有丝分裂活性。
