Heffner D K, Hyams V J
Cancer. 1984 May 15;53(10):2140-54. doi: 10.1002/1097-0142(19840515)53:10<2140::aid-cncr2820531025>3.0.co;2-y.
Twenty cases of a unique type of sinonasal tract neoplasm with combined histologic features of carcinosarcoma and teratoma are described and discussed. The term "teratocarcinosarcoma" is proposed and justified. Patients were adults (age range, 18-79 years; median age, 60 years). The variegated histologic components are illustrated and differences from gonadal germ cell neoplasms are delineated. This neoplastic entity is clearly malignant, with 60% of patients not surviving beyond 3 years (average survival, 1.7 years) following diagnosis, regardless of type of therapy. Aggressive therapy (combined surgery and irradiation) seems justified, however, since 40% of patients survived 3 years or longer with no current evidence of neoplasm (average follow-up, 6.1 years).
本文描述并讨论了20例具有癌肉瘤和畸胎瘤联合组织学特征的独特类型的鼻窦肿瘤。提出并论证了“畸胎癌肉瘤”这一术语。患者均为成年人（年龄范围18 - 79岁；中位年龄60岁）。文中展示了多样的组织学成分，并阐述了其与性腺生殖细胞肿瘤的差异。这种肿瘤实体明显具有恶性，60%的患者在诊断后3年内死亡（平均生存期1.7年），无论接受何种治疗。然而，积极的治疗（手术联合放疗）似乎是合理的，因为40%的患者存活了3年或更长时间，目前没有肿瘤迹象（平均随访6.1年）。
