Makalinao A U, Zaño F M
Clin Ther. 1984;6(2):185-92.
A randomized, double-blind study was done to determine the efficacy and safety of ranitidine in the short-term treatment of duodenal and benign gastric ulcers. Fifty-one patients with duodenal ulcer and 44 patients with gastric ulcer were admitted to the study. Forty-two duodenal ulcer patients and 36 gastric ulcer patients completed the study. In the duodenal ulcer group, 14 (70%) of 20 patients on ranitidine and one (4.5%) of 22 patients on placebo were healed. In the gastric ulcer group, 12 (75%) of 16 patients on ranitidine and six (30%) of 20 patients on placebo were healed. The healing percentages in both groups significantly favored ranitidine. Ranitidine was also significantly better than placebo in relieving ulcer pain. No side effect could be attributed definitely to ranitidine.
一项随机双盲研究旨在确定雷尼替丁在十二指肠溃疡和良性胃溃疡短期治疗中的疗效和安全性。51例十二指肠溃疡患者和44例胃溃疡患者纳入该研究。42例十二指肠溃疡患者和36例胃溃疡患者完成了研究。在十二指肠溃疡组，服用雷尼替丁的20例患者中有14例（70%）愈合，服用安慰剂的22例患者中有1例（4.5%）愈合。在胃溃疡组，服用雷尼替丁的16例患者中有12例（75%）愈合，服用安慰剂的20例患者中有6例（30%）愈合。两组的愈合率均明显有利于雷尼替丁。雷尼替丁在缓解溃疡疼痛方面也明显优于安慰剂。未发现明确可归因于雷尼替丁的副作用。
