泌乳大鼠乳腺的冷冻断裂观察。乳脂肪分泌过程中的膜事件。
Freeze-fracture observations of the lactating rat mammary gland. Membrane events during milk fat secretion.
作者信息
Peixoto de Menezes A, Pinto da Silva P
出版信息
J Cell Biol. 1978 Mar;76(3):767-78. doi: 10.1083/jcb.76.3.767.
Abstract
Membrane events during milk fat secretion were analyzed by freeze-fracture of the rat mammary gland. Two modes of milk fat secretion were observed: extrusion of fat droplets surrounded by a portion of the apical plasma membrane of the alveolar epithelial cells and, less frequently, release into the alveolar lumen of fat droplets contained in intracytoplasmic vacuoles. The extrusion process consists of two asynchronous events: clearing of membrane particles (probably including integral membrane proteins) and bulging of the apical plasma membrane. Most fat droplets are extruded with a bilayer membrane envelope (milk fat globule membrane) partially devoid of particles. The segregation of membrane particles may represent the onset of a process of structural degradation of the milk fat globule membrane.
摘要
通过大鼠乳腺的冷冻蚀刻技术分析了乳脂肪分泌过程中的膜事件。观察到两种乳脂肪分泌模式：脂肪滴被肺泡上皮细胞顶端质膜的一部分包围并挤出，以及较少见的细胞质内液泡中所含脂肪滴释放到肺泡腔中。挤出过程由两个异步事件组成：膜颗粒（可能包括整合膜蛋白）的清除和顶端质膜的鼓起。大多数脂肪滴被挤出时带有部分缺乏颗粒的双层膜包膜（乳脂肪球膜）。膜颗粒的分离可能代表乳脂肪球膜结构降解过程的开始。
相似文献
1
Freeze-fracture observations of the lactating rat mammary gland. Membrane events during milk fat secretion.泌乳大鼠乳腺的冷冻断裂观察。乳脂肪分泌过程中的膜事件。
J Cell Biol. 1978 Mar;76(3):767-78. doi: 10.1083/jcb.76.3.767.
2
Milk fat globule membranes devoid of intramembranous particles.不含膜内颗粒的乳脂肪球膜。
Cell Biol Int Rep. 1978 Jan;2(1):87-98. doi: 10.1016/0309-1651(78)90088-7.
3
Structure and dynamics of the bovine milk fat globule membrane viewed by freeze fracture.通过冷冻断裂观察的牛乳脂肪球膜的结构与动态
Exp Cell Res. 1980 Jan;125(1):127-39. doi: 10.1016/0014-4827(80)90197-4.
4
Fat droplet formation in rat lactating mammary gland and mammary carcinomas viewed by freeze-fracture.通过冷冻断裂观察大鼠哺乳期乳腺和乳腺癌中的脂肪滴形成。
Lab Invest. 1979 May;40(5):545-53.
5
Xanthine oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion.黄嘌呤氧化还原酶介导乳脂肪球的膜对接，但对于顶泌脂质分泌并非必不可少。
J Physiol. 2016 Oct 15;594(20):5899-5921. doi: 10.1113/JP272390. Epub 2016 Aug 3.
6
Functional regulation of xanthine oxidoreductase expression and localization in the mouse mammary gland: evidence of a role in lipid secretion.黄嘌呤氧化还原酶在小鼠乳腺中的表达及定位的功能调节：脂质分泌作用的证据
J Physiol. 2002 Dec 1;545(2):567-79. doi: 10.1113/jphysiol.2002.027185.
7
Histo- and cytophysiology of the lactating mammary gland of the African elephant (Loxodonta africana).非洲象（Loxodonta africana）泌乳乳腺的组织与细胞生理学
Cell Tissue Res. 1998 Dec;294(3):485-501. doi: 10.1007/s004410051200.
8
Antibodies to the major insoluble milk fat globule membrane-associated protein: specific location in apical regions of lactating epithelial cells.针对主要不溶性乳脂肪球膜相关蛋白的抗体：在泌乳上皮细胞顶端区域的特定定位。
J Cell Biol. 1981 Jun;89(3):485-94. doi: 10.1083/jcb.89.3.485.
9
Redox constituents in milk fat globule membranes and rough endoplasmic reticulum from lactating mammary gland.来自泌乳乳腺的乳脂肪球膜和粗面内质网中的氧化还原成分。
J Cell Biol. 1977 Apr;73(1):223-41. doi: 10.1083/jcb.73.1.223.
10
[Involution of the mammary gland. Enzyme histochemistry, elektron microscopy and radioautography (author's transl)].[乳腺的退化。酶组织化学、电子显微镜检查及放射自显影术（作者译）]
Prog Histochem Cytochem. 1976;9(2):1-58.
引用本文的文献
1
Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland.脂滴包被蛋白2促进脂滴与质膜的相互作用，从而促进小鼠乳腺分泌上皮细胞顶泌脂质的分泌。
Front Cell Dev Biol. 2022 Sep 9;10:958566. doi: 10.3389/fcell.2022.958566. eCollection 2022.
2
Symposium review: Intravital imaging of the lactating mammary gland in live mice reveals novel aspects of milk-lipid secretion.研讨会综述：活体小鼠泌乳乳腺的活体成像揭示了乳脂分泌的新方面。
J Dairy Sci. 2019 Mar;102(3):2760-2782. doi: 10.3168/jds.2018-15459. Epub 2018 Nov 22.
3
Butyrophilin controls milk fat globule secretion.嗜乳脂蛋白控制乳脂肪球的分泌。
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10385-10390. doi: 10.1073/pnas.0600795103. Epub 2006 Jun 26.
4
Origin and secretion of milk lipids.乳脂的起源与分泌。
J Mammary Gland Biol Neoplasia. 1998 Jul;3(3):259-73. doi: 10.1023/a:1018711410270.
5
Carotene in bovine milk fat globules: observations on origin and high content in tissue mitochondria.牛乳脂肪球中的胡萝卜素：关于其来源及在组织线粒体中高含量的观察
Lipids. 1980 Jan;15(1):33-8. doi: 10.1007/BF02534115.
6
Antibodies to the major insoluble milk fat globule membrane-associated protein: specific location in apical regions of lactating epithelial cells.针对主要不溶性乳脂肪球膜相关蛋白的抗体：在泌乳上皮细胞顶端区域的特定定位。
J Cell Biol. 1981 Jun;89(3):485-94. doi: 10.1083/jcb.89.3.485.
7
Glycosyl transferases in mouse and human milk fat globule membranes.小鼠和人乳脂肪球膜中的糖基转移酶
Mol Cell Biochem. 1984;58(1-2):157-63. doi: 10.1007/BF00240615.
8
An electron-microscope and freeze-fracture study of the egg cortex of Brachydanio rerio.斑马鱼卵皮质的电子显微镜和冷冻蚀刻研究。
Cell Tissue Res. 1991 Aug;265(2):317-28. doi: 10.1007/BF00398079.
9
Membrane fusion during secretion: cortical granule exocytosis in sex urchin eggs as studied by quick-freezing and freeze-fracture.分泌过程中的膜融合：通过快速冷冻和冷冻断裂研究海胆卵中的皮质颗粒胞吐作用。
J Cell Biol. 1979 Oct;83(1):91-108. doi: 10.1083/jcb.83.1.91.
10
Experimental studies of apocrine secretion in the dorsal prostate epithelium of the rat.大鼠背侧前列腺上皮顶浆分泌的实验研究。
Cell Tissue Res. 1979 Apr 30;198(1):145-58. doi: 10.1007/BF00234842.
本文引用的文献
1
2
Fine structure of the cow's udder during gestation and lactation.奶牛乳房在妊娠期和泌乳期的精细结构。
Lab Invest. 1961 Mar-Apr;10:238-55.
3
[Morphology of lactation; light & electro-microscopic studies on the mammary glands of rats].[泌乳的形态学；大鼠乳腺的光镜与电镜研究]
Z Zellforsch Mikrosk Anat. 1959;49(3):344-88.
4
[Not Available].[无可用内容]
FEBS Lett. 1972 Mar 15;21(2):220-222. doi: 10.1016/0014-5793(72)80141-8.
5
The presence of plasma membrane enzymes on the surface of bovine milk fat globules.牛乳脂肪球表面存在质膜酶。
FEBS Lett. 1971 May 10;14(4):230-232. doi: 10.1016/0014-5793(71)80624-5.
6
Studies of mouse mammary glands. I. Cytomorphology of the normal mammary gland.小鼠乳腺研究。I. 正常乳腺的细胞形态学。
J Natl Cancer Inst. 1967 Sep;39(3):459-90.
7
Studies on mammary gland involution. I. On the ultrastructure of the lactating mammary gland.乳腺退化的研究。I. 关于泌乳期乳腺的超微结构。
J Ultrastruct Res. 1968 Nov;25(3):193-213. doi: 10.1016/s0022-5320(68)80069-3.
8
Biochemical and morphological comparison of plasma membrane and milk fat globule membrane from bovine mammary gland.来自牛乳腺的质膜和乳脂肪球膜的生化与形态学比较
J Cell Biol. 1970 Jan;44(1):80-93. doi: 10.1083/jcb.44.1.80.
9
Physicochemical analyses of the bovine milk fat globule membrane. 3. Proton magnetic resonance spectroscopy.牛乳脂肪球膜的物理化学分析。3. 质子磁共振波谱法。
J Dairy Sci. 1972 Sep;55(9):1232-6. doi: 10.3168/jds.s0022-0302(72)85655-8.
10
Membrane splitting in freeze-ethching. Covalently bound ferritin as a membrane marker.冷冻蚀刻中的膜分裂。共价结合的铁蛋白作为膜标记物。
J Cell Biol. 1970 Jun;45(3):598-605. doi: 10.1083/jcb.45.3.598.
Zotero 插件