Schiff I, Tulchinsky D, Ryan K J
Fertil Steril. 1977 Oct;28(10):1063-6.
In order to study estrogen absorption from the vagina, 0.5 mg of unconjugated estrone (E1) or 17beta-estradiol (E2) was administered vaginally to 10 postmenopausal patients. A 29-fold increase in plasma E2 and a 4-fold increase in plasma E1 concentrations were observed 1 hour following the vaginal deposition of 0.5 mg of E2. Maximal decreases of 25% and 37% in plasma levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), respectively, were observed at 5 hours following treatment. One hour after vaginal administration of 0.5 mg of E1, a 24-fold increase in plasma E1 and a 3.7-fold increase in E2 were observed. These increases were associated with a 30% decrease in plasma FSH and LH. These data indicate that the vaginal administration of E2 or E1 may be used to achieve physiologic blood levels of these estrogens. They further suggest that vaginal estrogens not be used in patients in whom systemic estrogen therapy is contraindicated.
为了研究雌激素从阴道的吸收情况，对10名绝经后患者经阴道给予0.5毫克未结合的雌酮（E1）或17β-雌二醇（E2）。在经阴道给予0.5毫克E2后1小时，观察到血浆E2浓度增加了29倍，血浆E1浓度增加了4倍。治疗后5小时，观察到促卵泡激素（FSH）和促黄体生成素（LH）的血浆水平分别最大下降了25%和37%。经阴道给予0.5毫克E1 1小时后，观察到血浆E1增加了24倍，E2增加了3.7倍。这些增加与血浆FSH和LH下降30%有关。这些数据表明，经阴道给予E2或E1可用于使这些雌激素达到生理血液水平。它们进一步表明，全身雌激素治疗禁忌的患者不应使用阴道雌激素。
